Applications are invited for Postdoctoral Research Associate position in the laboratory of Professor Speck at Imperial College London ( http://www.specklab.com/ ). This post, funded by a highly competitive CRUK Discovery Programme Award , aims to uncover mechanisms that guarantee efficient human DNA replication employing genomic approaches. The project’s primary objective is to discover 1.) how DNA replication origins are specified through epigenetic mechanisms and specific recruitment factors and 2.) how DNA replication is regulated to allow faithful DNA replication. You will address how mutations in these processes contribute to genome instability and whether mutations that disrupt these mechanisms are enriched in cancer.
Duties and responsibilities
In the laboratory, you will plan and conduct cutting edge DNA replication research. In particular you will be in charge of high-resolution genomics (ChIP, ChIP-seq, ChIP-EXO/Cut&Run, synchronisation of human cells, bioinformatics analysis, RNAi, CRISPR) to address our overall biological questions. You will have the freedom to steer the research direction, collaborate with team members, supervise students and benefit from dedicated 1:1 and frequent ad-hoc meetings with the group head. Lab meetings, smaller subgroup meetings and related seminars (Biochemistry Club, Work-In-Progress Meetings, Institute-Wide Seminar Series and Happy Hours) provide a great frame work for knowledge exchange and project development. These innovative mechanistic studies will be carried out in a world-leading academic setting, in close collaboration with group members and external collaboration partners.
The current group consists of 12 researchers, including 5 postdocs, 5 PhD students, one lab manager and one technician. The successful candidate will enjoy intensive interactions with group members specialised in biochemistry and cryo-EM approaches generating a collaborative and highly productive atmosphere. We are excellent equipped for genomics (direct access to DNA sequencing facility and bioinformatics team) and proteomics (direct access to excellent local proteomics facilities).
By joining the group, the candidate will not only participate in high profile research projects but will also be directly mentored by Professor Speck in grant writing, networking and publishing. Indeed, the scientific framework and the support by Prof. Speck means that the candidates are well placed for a successful transition into independence.
The candidate should have a PhD in genetics, biochemistry or neighbouring disciplines, a strong publication record (published or submitted), very good expertise in troubleshooting and detailed knowledge of ChIP, ChIP-seq (ideally ChIP-EXO/Cut&Tag), library preparation, bioinformatic analysis, siRNA mediated knockdown, CRISPR to generate tagged protein cell lines and the synchronisation of human cells in the cell cycle. Background in the areas of nucleic acid-protein interactions, cell-cycle, chromatin biology, transcription, kinase regulation, molecular machines, or the broader area of genome stability would be of advantage, but is not necessary.
The position is fixed-term full time posts for 3 years with the possibility for extension. You will be based at the Hammersmith Campus in a brand-new building, providing an exceptional work environment and in proximity of the Imperial College Faculty of Medicine and the Chemistry Department. The start date is flexible and you should join anytime within the next 12 months.
Should you require any further details on the role please contact: Christian Speck – email@example.com .
The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published.For more information, see: https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/
The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research /
Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.
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