Research Assistant (Maternity Cover)

Department of Life Sciences

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Imperial College London, Exhibition Road, London, UK

Overview

  • Posted on: 18th Nov 2021
  • Salary: £36,694 - £39,888
  • REF: NAT01041
  • Closes: 02nd December 2021
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Job description

Job summary

The Department of Life Sciences was the top ranked university department in the UK for research intensity in Biological Sciences in REF2014 (Times Higher Education), scoring 100% on our environment.

The Bone Marrow Dynamics laboratory at Imperial College London led by Dr. Cristina Lo Celso is looking for a Research Assistant to join its dynamic team as a maternity and leave cover for 12 months. Research in the laboratory aims at understanding the cellular and molecular regulation of haematopoietic stem cells and leukaemia cells in the bone marrow microenvironment, with a special focus on cutting edge imaging and flow cytometry approaches, and in collaboration with mathematicians, physicists and engineers. This interdisciplinary approach allows us to unravel haematopoietic and stroma cells dynamics occurring during multiple types of stresses, from infection, to leukaemia development and stem cell transplantation (Lo Celso et al., Nature 2009; Rashidi et al., Blood 2014; Hawkins et al., Nature 2016; Duarte et al., Cell stem Cell 2018; Haltalli et al., NCB 2020).

You contribute to an exciting project funded by the Wellcome Trust and Cancer Research UK aiming to use multi-parameter immunofluorescence and flow cytometry analyses of in vivo models, and intravital time-lapse microscopy and image analysis to understand the mechanisms leading to haematopoietic stem cell and niche damage during severe infection and leukaemia growth.

You will work in the vibrant environment provided by the Imperial Department of Life sciences and the Imperial Centre for Haematology and will also have part time affiliation with the Sir Francis Crick Institute, where part of the work will take place. This is a tremendous opportunity for researcher, with access to state of the art technology platforms and world class peers at both Imperial and the Crick.

You will be responsible for day-to-day running of experiments, in particular contributing to and independently running microscopy and flow cytometry, experiments involving in vivo models, data analysis including AI pipelines, and using up-to-date techniques of cell and molecular biology and cell culture.

Duties and responsibilities

    • To prepare samples of haematopietic tissues and analyse them using ex vivo multiplex immunostainings and confocal and two photon microscopy,

 

    • To contribute to intravital microscopy sessions,

 

    • To perform flow cytometry analyses, bone sectioning, and other haematopoietic assays,

 

    • To analyse data with software such as FlowJo, ImageJ, Imaris, Prism, and deep learning Python scripts,

 

    • To contribute to the generation of in vivo models of stressed haematopiesis,

 

    • To contribute to the development of techniques, models and methods, for the collection and analysis of data,

 

    • To take initiatives in the planning of research and appropriate experiments,

 

  • To contribute to laboratory management eg through placing orders, re-stocking consumables, contributing to H&S related tasks, interacting with engineers and/or sales representatives.

Essential requirements

  • Hold a Master’s degree (or equivalent) in Biology or Biotechnology or a related field.

You must be able to demonstrate:

    • Research experience in the haematopoiesis, immunology, stem cell biology or tissue biology fields.

 

    • Proven experience in microscopy, ideally confocal and/or two photon microscopy of multiple fluorophores.

 

    • Experience with at least one of the following: in vivo models, multi-parametric flow cytometry, bone immuno-histology, haematopoietic assays, cryo-sectioning.

 

  • A clear understanding of Health and Safety regulations and procedures.

You must also be able to demonstrate:

    • Excellent verbal communication skills and the ability to deal with a wide range of people,

 

    • Excellent written communication skills and the ability to write clearly and succinctly for publication,

 

    • Ability to organise work and maintain clear and accurate records/documentation,

 

  • Ability to work as part of a team and to be open-minded and cooperative.

Further information

This is a full time, fixed term post for 12 months, based at South Kensington Campus.

Should you require any further details on the role please contact: Dr. Cristina Lo Celso – c.lo-celso@imperial.ac.uk or Kenny Oniti – k.oniti@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published.For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.

http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research /

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion

Additional information

Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework . Our values are:

  • Respect
  • Collaboration
  • Excellence
  • Integrity
  • Innovation

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

For technical issues when applying online please email support.jobs@imperial.ac.uk .

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