We are seeking to recruit a Research Assistant in the field of bioinformatics to work in a world-leading research group at the intersection of molecular biology and insect vector control. You will join the laboratory of Professor Andrea Crisanti based at the South Kensington Campus. Our research is based on cutting-edge molecular biology and genetics to understand and ultimately control the mosquito vectors of malaria. Our current focus is on the development of vector control strategies that are mainly based on gene drive systems. The projects typically involve generation of transgenic mosquito strains, genetic and phenotypic assays, mathematical modelling and multigenerational experiments to assess the effect and efficiency of the technology on caged populations.
Duties and responsibilities
As the dedicated bioinformatician for the group you will take initiatives in the planning of research and conduct data analysis. You will be required to maintain accurate and complete records of all findings and to provide bioinformatics assistance to Group members with Next-generation sequencing (NGS) data (e.g. RNA-Seq, scRNA-Seq, amplicon sequencing) from experiments with laboratory-reared mosquitoes and population genetics (e.g. individual genome re-sequencing) data. Based on input from researchers of the group, you will be able to execute suitable workflows and techniques to plan experiments for data collection, modelling and analyses. A key element of the role will be in helping to plan experiments in collaboration with wet lab researchers in order to ensure there is sufficient scientific power to answer the question at hand. A fundamental skill the applicant must possess is the ability to communicate their workflow and a breakdown of their analysis to a wide range of biologists that may not have a large amount of bioinformatics experience. You may also be required to collaborate with other allied scientists within Imperial College and elsewhere in London and abroad as appropriate.
You must have an MSc (or equivalent) with good amount of experience in an appropriate biological science or computational discipline with a strong focus on bioinformatics, computational biology and genomics.
You must hold a PhD (or equivalent) in an appropriate biological science or computational discipline with a strong focus on bioinformatics, computational biology and genomics.
Experience with next generation sequencing analysis is essential. The successful candidate must have strong programming skills (preferably R and/or Python) and high working proficiency in a Unix/Linux environment. Experience with high-performance computing (HPC) is a plus.
A good knowledge of molecular biology, genomics, transcriptomics is highly desirable. Previous work experience in the field of insect biology is preferred, but not essential.
You must have excellent verbal and written communication skills. You must also be able to develop and apply new concepts and have a creative approach to problem-solving. The ideal candidate will have the passion and drive to tackle and overcome scientific problems.
This is a full time, 24-month fixed-term position with a possibility of extension.
*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,045 – £39,183 per annum
For informal enquiries please contact Professor Andrea Crisanti (via firstname.lastname@example.org ) or Dr Federica Bernardini ( email@example.com )
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Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.
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