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Research Associate Biochemistry

Institute of Clinical Sciences

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Imperial College London, Exhibition Road, London, UK

Overview

  • Posted on: 28th Jan 2021
  • Salary: up to £48,340
  • REF: MED02240
  • Closes: 11th February 2021
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Job description

Job summary

The DNA replication group, Imperial College London, is looking to recruit a motivated and highly creative Research Associates interested in understanding how the eukaryotic replicative helicase promotes accurate DNA replication using biochemical approaches.

One of the most fundamental property of all living things is the ability to replicate their DNA, which allows cells to pass on their genetic material from parent to progeny. The Speck’s lab reconstituted eukaryotic replicative helicase loading with purified Saccharomyces cerevisiae proteins and identified the MCM2-7 double-hexamer as the template for replication fork assembly (Evrin et al PNAS 2009).

We are now in a strong position to address how the replicative helicase becomes activated for DNA synthesis.

The candidates will employ our well-established in vitro reconstituted system (Evrin et al PNAS 2009; Noguchi et al PNAS 2017) to study how the replicative helicase becomes activated during S-phase.

Duties and responsibilities

  • To generate reagents for the project
  • To design and carry out scientific experiments in accordance with the project
  • To maintain highly organised and accurate records of experimental work
  • To prepare material for presentation in oral and poster formats and present findings to colleagues and at conferences
  • To contribute to writing bids for research grants
  • To analyse, manage and communicate data, ensuring the validity and reliability of the data at all times
  • To draft publications and prepare them for submission to refereed journals
  • To submit publications to refereed journals
  • To actively contribute to the smooth running of the laboratory in co-ordination with other members of the group
  • To form a good working relationship with other members of the group and actively participate in team work
  • To promote the reputation of the group, Centre, the Department and the College
  • To develop contacts and research collaborations within the Centre, the College and the wider community
  • To supervise staff, as appropriate, and to provide guidance and occasional supervision to junior members of the laboratory, if requested
  • To actively participate in the group’s research meetings and academic activities organised by the Institute (including internal seminars, lectures, institute retreats and public-related activities)

Essential requirements

  • Research Associate: Hold a PhD (or equivalent) in Epidemiology or medical statistics or a closely related discipline
  • Research Assistant: Near completion of a PhD (or equivalent) in Epidemiology or medical statistics or a closely related discipline
  • Epidemiology or medical statistics or a closely related discipline
  • Have excellent experience in protein biochemistry of replication factors, biochemical assays and the preparation of samples for cryo-EM analysis
  • At least one first-author publication in an internationally recognised peer-reviewed journal (published)
  • Strong experience in preparing samples for cryo-EM
  • Strong experience in protein expression, purification of replication factors
  • Solid knowledge in working with purified proteins

Further information

This post is based at the Hammersmith Campus in London for a period of 6 months.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,045 – £39,183 per annum

For technical issues when applying online please email recruitment@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published.For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research /

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations:

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

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