Research Associate in Photoswitches and Photopharmacology

Department of Chemistry

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Imperial College London, Exhibition Road, London, UK

Overview

  • Posted on: 01st Feb 2021
  • Salary: £40,858 - £48,340
  • REF: NAT00851
  • Closes: 01st March 2021
  • Contract Type: Permanent
  • Hours: Full Time

Job description

Job summary

A Research Associate position in photoswitches and photopharmacology is available within the Chemistry Department at Imperial College, London, based at the new White City campus. You will join the group of Prof. Matthew Fuchter ( https://www.imperial.ac.uk/fuchter-group ) building on the group’s successful track record in the development and application of novel molecular photoswitches. Specifically, the Fuchter group has recently shown the high potential of heteroaromatic azo photoswitches ( J. Am. Chem. Soc. 2014, 136 , 11878; J. Am. Chem. Soc. 2017, 139 , 1261; ChemPhotoChem. 2019, 3, 372 ), applying these to a range of light-addressable functional applications (e.g. J. Am. Chem. Soc. 2020 , 142, 8688; J. Am. Chem. Soc. 2020, 142 , 17457). This project will have a particular focus on applying such switches to photopharmacology, an area of high interest to the group ( J. Med. Chem . 2020, 63 , 11436).

The project forms part of an exciting large-scale initiative with the University of Hong Kong and Peking University. With funding from the Innovation and Technology Commission, the Laboratory for Synthetic Chemistry and Chemical Biology has been created at the University of Hong Kong. Imperial College is a lead collaborator and several research programmes, including this one led by Prof Fuchter, will be housed in the Department of Chemistry, Imperial College (other PIs are Profs Tate, Vilar and Long) but connected to the Laboratory. There will be opportunities for collaboration, travel and research placements in Hong Kong.

The research aims to further the science of heteroaromatic photoswitches, improving the performance of these systems, particularly for application to biological problems. Alongside this, this project will seek to apply the switches developed to one or more ongoing photopharmacological projects. Such multidisciplinary work will allow for the exciting development of light dependent chemical probes. The research will involve a range of techniques from synthetic organic chemistry and photochemistry, to chemical biology.

Duties and responsibilities

We are looking for someone with prior experience in the synthesis and characterisation of molecular photoswitches and their application to one or more functional applications. Additional experience in chemical biology is desirable but not essential. This role will encompass varied responsibilities, including work on a wide range of collaborative projects. You will develop new photoswitch scaffolds, from a design phase, thorough to synthesis and rigorous physical characterisation. In addition, you will be heavily involved in the application of such switches to one or more photopharmacology projects, which could involve peptide, protein or cell work. This project will involve collaborations with research groups across Imperial College and the University of Hong Kong and drive the development and translation of photopharmacology.

Essential requirements

  • A PhD degree (or equivalent) in Chemistry
  • Experience and knowledge of advanced organic chemistry
  • Experience and knowledge of photoswitch characterisation
  • Experience and knowledge of advanced photoswitch applications
  • A track record of publications commensurate with career stage
  • Excellent verbal and written communication skills and the ability to deal with a wide range of people

Further information

*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,045 – £39,183 per annum

The Department of Chemistry proudly holds an Athena SWAN Gold Award and strives to provide a working environment where all our staff feel fully supported to flourish and excel. The Department of Chemistry is committed to promoting the wide range of Family Friendly policies and associated initiatives offered by the College.

For informal enquiries about this position please contact Prof. Matt Fuchter ( m.fuchter@imperial.ac.uk )

For technical issues when applying online please email recruitment@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published.For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.

http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research /

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations:

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

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