Research Technician in Epigenetics of Neurobiology

Department of Brain Sciences

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Imperial College London, Exhibition Road, London, UK


  • Posted on: 23rd Feb 2021
  • Salary: £29,738 - £32,593
  • REF: MED02287
  • Closes: 22nd March 2021
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Job description

Job summary

Dementia is the greatest health challenge of our century.

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.

The UK DRI at Imperial brings together researchers from diverse backgrounds with fresh perspectives, drawing on the university’s unique strengths, resources and focus on science, engineering, medicine and business. The team recognises that the challenges of dementia demand new concepts, new approaches and a diverse range of new research tools and directions. Their holistic approach views the ageing brain in the context of the ageing body, not in isolation.

This research area is evolving rapidly. The post holder will be given opportunities to train in new methods and develop new competencies. Imperial also encourages continued professional development through both internal and external educational courses covering skills such as project, financial or time management and communication, as well as scientific topics. The post holder also will be supported to attend scientific meetings to present work, subject to progress and budgets.

Duties and responsibilities

In this role, you will support a growing research team in the UK DRI Centre at Imperial with technical support for single cell epigenetics in neurodegenerative diseases. For example, you will support the development of new methods for enriching nuclei of rare cell types from post-mortem human brain.

This will involve testing of new antibodies, as well as cutting edge methods for fluorescent sorting based on RNA. You will also be involved in developing, scaling up and applying new plate-based single-cell genomic methods. This project will involve working with human tissue brain banks and will be involved in sourcing and validating the samples.

You will work within a mission-focused team of experimental and computational biologists as well as collaborating with neuropathologists and brain banks. Our centre of the UK DRI has made a strong commitment to neurogenomics and epigenetics, providing a critical mass of closely collaborating research groups. In addition to research support, the duties will include laboratory administrative responsibilities.

Essential requirements

  • A qualification in relevant laboratory sciences, biology, one of the biomedical or related sciences or equivalent vocational qualification or relevant laboratory-based experience
  • Experience in laboratory-based research
  • Practical experience with genomics methods and biological tissue management
  • Computer literacy using Microsoft Word, Excel and PowerPoint
  • Experience in some or all of the following techniques:
      • Handling of cryopreserved tissues
      • DNA extraction
      • RNA extraction and quality assessment
      • ATAC sequencing
      • Single cell or single nuclear genomics methods
      • In situ hybridisation methods
      • FACS analyses
      • RNA extraction and quantification
      • PCR
      • Western Blotting

Further information

This post is offered as a Full time and Fixed term of 2 years, with potential for extension.

You will be working in the new Sir Michael Uren Hub, White City Campus with access to resources in the Department of Brain Sciences with research labs in the Burlington Danes Building of Hammersmith Campus.

Should you have any queries please contact Dr Nathan Skene,

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations:

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

For technical issues when applying online please email .

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