• Posted on: 02nd Nov 2021
  • Salary: £33,114 to £35,844 per annum, including London Weighting Allowance
  • REF: 036006
  • Closes: 07th November 2021
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Job description

We are looking for a dynamic and motivated Research Assistant to work with us on defining the role of the immune system in myeloid leukemias.

You will work in our new lab at King’s College London and will support research projects aimed at teasing apart the pro and anti-leukemia components of the T cell response in patients with Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML), and how these are modulated by therapeutic treatments.

The successful applicant will be a key researcher in programs to investigate the immunological landscape in Age-related Clonal Haematopoiesis (ARCH) MDS and AML patients.

The post-holder will apply state-of-the-art single cell technics, and in particular single cell TCRseq and T cell cloning to characterize the specificity T cell populations associated with disease progression or therapeutic benefit in samples from AML and MDS patients.

This work will be done in a collaborative multidisciplinary environment including immunologists, haematologists and bioinformaticians working at the interface between basic and translational immune-haematology.

The successful applicant will be expected to have background knowledge in tumor Immunology and a keen interest in antigen specific T cell responses, in particular against.

The post-holder will be supervised by Dr. Giorgio Napolitani (giorgio.napolitani@kcl.ac.uk).

This post will be offered on a fixed-term contract for 1 year

This is a full-time post – 100% full time equivalent.

Skills, knowledge, and experience

Essential criteria

1. Hold a relevant undergraduate and master degree or be close to completion

2. Evidence of significant academic attainment and interest in the area

3. Ability to manage own academic research and associated activities

4. Experience of working in a research team

5. Excellent communication skills, and ability to describe clearly scientific data

6. Evidence of good reasoning skills
Further information

Dr Napolitani’s group is part of a research program at the Comprehensive Cancer Centre dedicated to translating research into better treatments for patients. The other groups focused on blood cancers include: Haematology Group (Dr Lynn Quek), Leukaemia Stem Cell Biology (Professor Eric So), Gene & Cell based therapies (Professor Farzin Farzaneh), CAR-T Cell Programmes (Dr Reuben Benjamin), bone marrow failure syndromes (Professor Ghulam Mufti, Dr Austin Kulasekararaj), post-transplant immunotherapies (Professors Francesco Dazzi, Dr Pramila Krishnamurthy and Dr. Victoria Potter) and King’s College Hospital Haemato-oncology Molecular Diagnostics Centre (Dr Deborah Yallop, Dr Shireen Kassam and Dr Guy Hannah).

These research programs benefit from an extensive Biobank of blood cancers, and a recent investment in infrastructure and new equipment. Research groups at Denmark Hill will have on-site access to a BD Aria Fusion Flow Sorter, BD Lyric Flow Analyzers, a Helios CyTOF, an Illumina NextSeq Sequencing System, 10x Genomics Chromium platform and automated sample and nucleic acid handling systems. These research programs are closely linked to clinical services, where research activities are translated into novel therapies including CAR-T cells/immunotherapies (with specific emphasis on allogenic CART-T clinical trials in Lymphomas/ALL & AML).

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