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Research Assistant

Comprehensive Cancer Centre

London, Guy's Campus

Overview

  • Posted on: 20th Jan 2022
  • Salary: £34,906 per annum, including London Weighting Allowance
  • REF: 039985
  • Closes: 20th February 2022
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Job description

Cancer Research UK (CRUK) have awarded funding to the CRUK City of London (CoL) Centre to create a CRUK Radiation Research Unit (RRU). The unit will feature an ambitious research programme for radiation oncology and radiation biology called RadNet. This network, is CRUK’s largest ever investment in radiotherapy research, is aimed to accelerate the development of advanced radiotherapy techniques, challenging the boundaries of this mainstay treatment through world-first exploratory projects.

RadNet core themes are:

• The mechanisms of radiation resistance, including cancer evolution and cancer stem cells.

• How the tumour microenvironment and immune system affect the response to radiotherapy.

• Advanced radiotherapy techniques, such as proton beam therapy and stereotactic radiotherapy, which uses multiple beams of radiation that converge on the tumour.

• Personalising radiotherapy using artificial intelligence and improved tumour imaging.

• Radiotherapy for children and young people’s cancers.

The CoL Centre is a world-class hub for cancer biotherapeutics. It brings together researchers from four of the central London Cancer Research UK centres: University College London, King’s College London, Barts / Queen Mary University of London and the Francis Crick Institute. This unique interdisciplinary and collaborative network will generate novel innovative therapies, diagnostics and stratification strategies in addition to providing a clinical and translational pipeline for cancer discovery science.

The London partners will also work closely with University College London Hospitals NHS Foundation Trust, Guy’s and St Thomas’ NHS Foundation Trust and Barts Health NHS Trust.

Main purpose of the job

The main objective of the post-holder will be the development of in vitro lung cancer models to address a range of biological questions for CRUK RadNet City of London RRU with the ultimate aim of designing radiotherapy/immunotherapy combination protocols. Through interaction with CRUK RadNet City of London’s collaborators, work will focus on the identification and characterization of changes in myeloid cells in response to radiation and IO combinations. The use of high number multi-marker spatial analyses of tissue microenvironment will be crucial. This will enable the progression of fundamental translational research methodologies that bridges the gap between academia, industry and the clinic, promoting collaboration across the fields.

The post-holder will be directly supervised by Dr Rachel Evans.

This post will be offered on an fixed-term contract for 12mths

This is a full-time post – 100% full time equivalent

Key responsibilities

  • In vitro cancer studies focusing on combining radiation and IO agents in 2D and 3D lung cancer co-cultures
  • Multi-parameter flow cytometry of in vitro co-cultures
  • Processing and analysis of in vitro co-cultures using immunofluorescence, confocal microscopy and multiphoton microscopy

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.

Skills, knowledge, and experience

Essential criteria

1. MSc in Cancer or related subject

2. Experience in tissue culture

3. Training and experience in multiparameter flow cytometry

4. Training and experience in confocal microscopy

5. Experience of mass cytometry (sample preparation and downstream analysis)

6. Good presentation skills

7. Interest in cancer research

8. Hardworking and ability to prioritise work

9. Willingness to learn new skills

Desirable criteria

1. Knowledge and experience with multiphoton microscopy

2. Experience in live cell imaging

3. Knowledge and experience with molecular and cell biological techniques

Further information

This post is subject to Occupational Health clearance.

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