A CRUK-funded Research Assistant (RA) position is available immediately in our Molecular Addictions Team to characterize the non-catalytic functions of AKT, and assess novel AKT-targeting therapeutic approaches. The goal is to understand the molecular basis for the contribution of AKT function to the maintenance of cancer cell survival, in particular through modulation of cellular metabolism. Our strategy involves a combination of molecular pharmacology, biochemistry, and omics-based molecular profiling. In addition to the research, the successful candidate will be expected to help with the general maintenance of the lab. This will include making sure that all lab equipment is functioning properly and calling for service when necessary, placing lab orders, and preparing common reagents for the lab.
Applicants should possess a masters degree in molecular biology/cell biology/molecular pharmacology or a related subject. Previous experience of basic cell and molecular biology or biochemistry in a work-based laboratory environment is essential. Experience in cell culture is also required. Duties will also include general maintenance of the lab (e.g. preparation of common reagents, ordering, and maintenance of plasmid and cell line databases), and occasional collection of clinical samples from our clinical collaborators at King’s College Hospital.
Starting salary will be in the range £37,292 and will be for 20 months in the first instance. This post also benefits from generous annual leave entitlement and defined benefit pension scheme. Further information can be found in the full job description.
This post will be offered on an fixed-term contract for 20 months
This is a full-time post – 100% full time equivalent
- Carry out experiments and become familiar with relevant techniques related to the primary project (i.e. characterisation of AKT function).
- Become familiar with the principles and maintenance of the equipment. This includes the Cell Viability analyser, GelCount scanner, and general laboratory equipment.
- Ensure that work carried out conforms to all the rules and regulations of the institute.
- Initiate laboratory procedures to ensure smooth running of experimental work and with others ensure that housekeeping tasks are performed on a regular basis
- Ensure that accurate records of experimental data are maintained in both laboratory notebook and electronically
- Initiate purchase of consumables items within budgetary limits
- Occasionally collect and process clinical samples from collborators at King’s College Hospital.
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience
1. Masters degree in Biochemistry/Pharmacology or related subject.
2. Demonstrable experience of laboratory work e.g. sandwich placement or postgraduate work.
3. Use of software and databases to record and analyse results.
4. Experience with biochemical and/or cell based assay techniques.
5. Experience with mammalian tissue culture work.
6. Good organisational skills
7. Self-motivated and enthusiastic, with a keen desire to produce high quality scientific data
8. Willingness to learn new techniques/approaches
9. Computer literate with ability to use e.g. MS Office, web-based tools and databases.
10. Good observation skills, attention to detail and ability to keep appropriate records.
- Molecular pharmacology experience in an industrial or academic setting.
- Demonstrable knowledge of analytical methodology.
This post is subject to Disclosure and Barring Service and Occupational Health clearance.