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Research Associate

Department of Infectious Diseases

London, Guy's Campus

Overview

  • Posted on: 19th Jan 2022
  • Salary: £38,3826 to £43,239 including London Weighting Allowance
  • REF: 039886
  • Closes: 16th February 2022
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Job description

A joint UK-Indian MRC-DBT funded 18-month postdoctoral research associate position is available immediately in the laboratories of Professor Stuart Neil and Dr Annapurna Vyakarnam. As part of a large collaborative grant between King’s College London and the St John’s Research Institute in Bangalore to characterize the basis of differential immunopathology of COVID-19 in South Asians in the UK or in India, we aim to study variation in innate immune responses and its relationship to the pathogenesis of variants of SARS CoV-2.

We are seeking a motivated and hard-working postdoctoral research associate to join our team to assess innate immune responses in healthy and infected people recruited to the study. The project will entail handling and assaying primary patient material and will include in vitro immunological and virological experiments using live SARS CoV-2 as well as multiparameter flow cytometry, RNAseq and bioinformatic analyses. There may be potential for short secondments to India, COVID19 travel restrictions permitting.

The successful candidate will have a PhD in molecular/cellular immunology or infectious disease with extensive experience of handling human primary cells for immunological characterization. Excellent organization, record-keeping and presentational skills are essential. Prior experience in the analysis of RNAseq data and bioinformatics will be an advantage.

This post will be offered on an a fixed-term contract until 30/09/2022 .

This is a full-time post – 100% full time equivalent

Key responsibilities

  • Day-to-day organization and running of the experimentation related to the project
  • Supervision of a research assistant associated with the project
  • Record keeping and data analysis
  • Writing of scientific papers
  • Presenting data at internal lab and departmental seminars and at international scientific meetings.
  • Collegial responsibilities to the management of the laboratory as part of the team

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience

Essential criteria

• A PhD or equivalent in Immunology, infectious disease or relevant biomedical science

• Extensive experience in molecular biology and biochemistry

• Isolation, propagation and flow cytometric analysis of primary human blood cells

• Mammalian cell culture and manipulation including transfection, CRISPR and RNAi, or lentiviral-based vectors.

• Track record of publication of primary research

• Excellent communication and presentational skills

Desirable criteria

• Experience with the culture and molecular manipulation of mammalian viruses

• Bioinformatics analyses of gene expression or proteomics datasets
Further information

At interview, candidates will be required to present a 30 minute summary of their previous research and meet with various member of the group and department throughout the day.

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