The Centre for Stem Cells & Regenerative Medicine is located in Guy’s Hospital.
It is internationally recognized for research on adult and pluripotent stem cells and is a focus for cutting-edge stem cell research currently taking place across the College and its partner NHS trusts, as part of King’s Health Partners. Through the Centre, King’s aims to drive collaboration between scientists and clinicians to translate the potential of stem cells into clinical reality for patients.
Applications are invited for a postdoctoral researcher funded as part of the PIs Wellcome Clinical Fellowship, and will work with a dynamic group of scientists focussed on reproductive biology, early embryonic development and the causes of infertility. The post holder will contribute to the regenerative medicine theme and will be involved in the generation and processing of single cell experiments using a variety of techniques.
This is an exciting opportunity following our recent work (Sangrithi et al. 2017, Dev Cell & Lau et al. 2020, Dev Cell). The project aims to discover the function of genes on the X-chromosome in male germline stem cells (spermatogonia) and their role in idiopathic and sex chromosome aneuploidy associated infertility. We aim to understand physiological gene regulatory networks functional in spermatogonial stem cells using a combination of single-cell methods, to explain how perturbation in X-gene dosage in SSCs may cause infertility. The postholder will also identify and validate candidate disease bio-markers.
This post will be offered on an a fixed-term contract until 05/04/2026
This is a full-time post – 100% full time equivalent
• Carry out world class research.
• Are adept at working in a wet lab setting with experience in designing and executing experiments.
• Familiarity in single cell work nucleic acid manipulation is desirable
• Communicate results effectively in writing and orally
• Contribute to publications arising from the research projects
• Keep clear and up-to-date records of work
• Attend and present at seminars, journal clubs and conferences
• Contribute to collaborative atmosphere of the department
• Share skills by training others
• Comply with all relevant safety legislation to ensure a safe working environment
• Take part in public engagement activities
• To support grant writing, for maintaining the continual research in this domain, e.g. Fellowships
• Post holder will be expected to plan and prioritise their own workload, with competing and shifting priorities under pressure of deadlines
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience
• PhD awarded in the biological sciences
• Excellent general knowledge of molecular biology
• Knowledge of cell biology
• Knowledge of flow cytometry
• Relevant postdoctoral experience
• Experience in a molecular biology research lab
• Excellent record keeping / attention to detail
• Organized and systematic approach to research
• Pro-active, enthusiastic, positive attitude
• Self-motivated, with the ability to work under pressure & to meet deadlines
• Keen interest in infertility and regenerative medicine
• Ability to think strategically
• Understanding of the biology of germ cells and embryo development
• Previous experience in working with the laboratory mouse
• ES cell culture experience
• General knowledge of computational tools for single cell RNAseq
• Ability to make collaborative and independent decisions
*Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.
ABOUT THE SCHOOL
The School of Basic & Medical Biosciences is led by Professor Mathias Gautel and comprises five departments with a wide range of expertise and interests. Using a bench to bedside approach, the School aims to answer fundamental questions about biology in health and disease and apply this to the development of new and innovative clinical practise, alongside providing a rigorous academic programme for students.
The Centre for Human & Applied Physiological Sciences (CHAPS) uses an integrative and translational research approach focusing on fundamental questions about human physiological function in health and disease to explore 3 research themes: skeletal muscle & aging, sensory-motor control & pain and aerospace & extreme environment adaptation.
The Centre for Stem Cells & Regenerative Medicine focuses on cutting-edge stem cell research, how stem cells interact with their local environment and how these interactions are important for developing effective cell therapies in the clinic.
The Department of Medical & Molecular Genetics uses cutting-edge technologies and analysis techniques to explore the mechanistic basis of disease, improve diagnostics and understand the epigenetic mechanisms of gene regulation and RNA processing, working from whole population level to complex and rare disease genomes
The Randall Centre of Cell & Molecular Biophysics takes a multi-disciplinary approach at the interface of Biological and Physical Sciences to explore the underlying mechanisms behind common diseases.
St John’s Institute of Dermatology seeks to improve the diagnosis and management of severe skin diseases, through a better understanding of the basic pathogenetic mechanisms that cause and sustain these conditions focussing on cutaneous oncology, genetic skin disorders, inflammatory & autoimmune skin disorders, and photomedicine.
About the Department of Centre for Stem Cells & Regenerative Medicine
The Centre for Stem Cells & Regenerative Medicine is led by Professor Fiona Watt, who’s laboratory comprises approximately 30 research staff and visiting scientists and is internationally recognised for research on adult and pluripotent stem cells. Along with Professor Watt’s group there are nine other research groups operating at the Centre, bringing the total number of staff to approximately 80 people.
Research at the Centre is focused on how stem cells interact with their local environment, or niche. We believe that an understanding of these interactions is important for developing effective cell therapies in the clinic. Located on the Guy’s Hospital campus, the Centre acts as a focus for cutting-edge stem cell research taking place across the College and its partner NHS Trusts, as part of King’s Health Partners. To facilitate collaborations within King’s and with external partners, we have opened a ‘Stem Cell Hotel’ where researchers can access specialist equipment and technical support to study stem cell behaviour at single cell resolution. We also host an international seminar series and run the ‘Stem Cells @ Lunch’ seminar series to share ideas and unpublished data. Our researchers are committed to public engagement and take part in diverse outreach events.Detailed information about the Centre for Stem Cells & Regenerative medicine can be found in the link below: