Research Technician

Developmental Neurobiology

London, Guy's Campus

Overview

  • Posted on: 11th Feb 2021
  • Salary: £32,676 - £37,297 per annum, including London Weighting Allowance
  • REF: 016028
  • Closes: 11th March 2021
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Job Description

Applications are invited for a Research Technician to work in the laboratory of Dr Adil Khan, in the Centre of Developmental Neurobiology at King’s College London.

The successful candidate will undertake original and state of the art biomedical research as an integral member of a group studying cognitive behaviour in mice. Projects will include studying the role of sensory cortex and/or prefrontal cortex in task-switching behaviour in mice, to understand neural circuit mechanisms underlying flexible behaviours. The successful candidate will also provide flexible logistical, technical and organisational support to other group members in the laboratory.

Applicants should have an MSc in Neuroscience/Biological Sciences and have a background working in neuroscience, preferably including mouse husbandry, stereotaxic surgeries, perfusions, immunostaining and animal behaviour. Candidates should be motivated, a team-player and be able to manage a complex work load.

This post will be offered on a fixed-term contract for 1 year (extendable).

This is a full-time post – 100% full time equivalent.
Key responsibilities

  • Undertake original and state of the art biomedical research as an integral member of a group working on neural circuits underlying flexible, cognitive behaviour in mice.
  • Carry out behavioural training of mice on existing paradigms studied in the lab, involving careful handling and head-fixation of mice
  • Carry out stereotactic surgical procedures on mice including cranial window implants and viral injections in targeted brain areas.
  • Carry out perfusions and obtain tissue sections of mouse brain for staining and imaging
  • Carry out immunohistochemistry and histological stains to localise different markers in tissue sections, confocal and brightfield imaging of preparations.
  • Breeding and maintenance of several transgenic / mutant mouse lines
  • Maintain up-to-date, accurate and comprehensive laboratory notes
  • Assist, supervise and train other members of the group, including students and other research staff in their application in related lab projects.

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience

Essential criteria

  • MSc in Neuroscience/Biological Sciences or equivalent experience
  • Experience working with mice, including handling and breeding
  • Experience working with neural tissue, such as recording, perfusion, slicing, staining, imaging
  • Familiarity with neural circuit-level questions

Desirable criteria

  • Knowledge and skills in mouse behavioural work
  • Knowledge of and practical skills for histology, cell biology and molecular biology
  • Experience of microscopy, such as confocal or 2-photon microscopy
  • Experience of a wide range of histological techniques

Further information

The selection process will be a panel interview.

For an informal discussion to find out more about the role please contact Dr Adil Khan khan.adil@kcl.ac.uk.

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