Research Assistant/Associate: Proteomics in “Ubiquitylation in Innate Immunity”

Faculty of Humanities & Social Sciences

Newcastle University, Newcastle upon Tyne, UK


  • Posted on: 17th Feb 2021
  • Salary: £28,331.00 - £40,322.00 per annum
  • REF: 5820
  • Closes: 10th March 2021
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

Salary: £28,331.00 – £40,322.00 per annum

Closing Date: 10 March 2021

The Role

You are invited for a post-doctoral position to work in the group of Prof Matthias Trost studying how innate immune responses triggered by bacterial infection of macrophages are regulated by ubiquitylation. Ubiquitylation is an important post-translational modification regulating all biology, including inflammation and cancer. We have recently identified key E3 ligases regulating immune responses and the project will characterise the molecular mechanisms of these E3 ligases and general ubiquitylation responses. The project will exploit the laboratory’s expertise in proteomics, biochemistry and cell biology techniques. Recent papers from our lab include articles in top journals such as EMBO Journal and Nature Microbiology.

You should be a talented and enthusiastic post-doctoral scientist with a background in either molecular immunology, biochemistry, cell biology or infection biology. You will have a good academic track record and have published at least one first authored paper in an international journal. You will ideally have experience with cell biological and biochemical techniques. Knowledge and working experience in proteomics, ubiquitylation and animal/mouse handling would be advantageous, but is not essential as training can be provided.

The position is available for 3 years with a possibility for further extension. Available immediately, but later start dates will be taken into consideration.

The position is based in the Newcastle University Biosciences Institute (NUBI). In the last Research Excellence Framework (REF2014) by the UK government, our institute (then called ICaMB) was 1st for research output amongst all of the UK submitted University biosciences departments and was placed 5th out of 44 UK submissions in the overall scores.

Newcastle upon Tyne is a vibrant city in the northeast of England. In addition to an excellent scientific environment, Newcastle offers an affordable standard of living in an area of outstanding natural beauty with beautiful beaches at the coast and Northumberland countryside.

Further information can be obtained by contacting Prof Matthias Trost via email ( or from the lab’s website:

As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

Key Accountabilities

• Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements.
• Plan and carry out independent original research encompassing:

  • Investigations leading to the discovery of new knowledge
  • Analysing data, interpreting and bringing new insights

• Initiate or participate in inter-disciplinary collaborations as agreed with supervisor.
• Provide guidance, where necessary, to other staff and students including possible supervision of PhD and undergraduate project students as agreed with supervisor.
• Present research findings as posters and oral presentations at conferences.
• Write up research findings for publication and dissemination.

The Person



• Degree in biology, biochemistry, immunology, chemistry or a related area.
• Possession of a PhD (or imminent submission of thesis) in biology, immunology, biochemistry, chemistry or a related field. If you are close to submission of PhD you will be appointed at Research Assistant level initially.

Knowledge, Skills and Experience


• A strong research background in cell biology, biochemistry or molecular immunology.
• Experience with standard biochemical techniques such as Western Blotting.
• Experience with cell culture.
• At least one first-author publication in a recognised peer-reviewed journal (published or submitted).


Experience with proteomics analysis or willingness to learn.
• Experience of cell biological methods such as microscopy.
• Experience with macrophages or other innate immune cells.
• Experience with cell signalling.
• Experience of presenting research work at scientific meetings.
• Ability to contribute to writing publications.

Attributes and Behaviour


• You should be ambitious with a demonstrable drive to succeed and produce work at the highest level.
• Ability to work independently.
• Strong interpersonal skills and ability to work in a team.
• Capacity for original thought.

• Willingness to take on extra responsibilities, such as the day to day supervision of PhD and undergraduate project students.
• Willingness to work flexibly by mutual agreement.

Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains staff from all sectors of society. We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent. We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.

The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality. The University also holds the HR Excellence in Research award for our work to support the career development of our researchers, and is a member of the Euraxess initiative supporting researchers in Europe.

Requisition ID: 5820

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