NDM Experimental Medicine, Peter Medawar Building, Oxford
Grade 8: £42,149 – £50,296 p.a.
We seek a Postdoctoral Scientist to work on a research project seeking to develop and evaluate new technologies in genome detection for blood donation screening and wider diagnostic detection of viral pathogens. The effectiveness of next generation sequencing (NGS) and the implementation of several strategies to enhance its analytical sensitivity will be evaluated against existing PCR-based assays for defined pathogens, such as HCV, HIV and HBV currently screened in blood and organ donors. The project will develop recent advances in nucleic acid binding methodologies coupled to genome amplification, for example using CRISPR cas9/13-coupled guide RNAs. The work is a component of a large research unit programme funded the National Institute for Health Research (NIHR) entitledGenomic Revolutions in Donation Screening and Safety(GRiDSS), designed to exploit advances in new molecular detection and genetic characterisation technologies for viruses and other organisms.
The appointee will direct and participate in a series of research and development programmes in the Wellcome Genome Centre, University of Oxford, designed to enhance the sensitivity and specificity of NGS methods for defined pathogens and potentially wider metagenomic screening. The appointee will be working under supervision of Dr Tanya Golubchik, Big Data Institute, NDM, and will participate in wider Research Unit activities with other post-docs, theme leads and the Unit Director, Professor Peter Simmonds. The appointee may provide laboratory supervision for one or more PhD students enrolled in the programme.
As a Post-doc research fellow, you will hold a relevant PhD/DPhil in a virology, microbiology or molecular biology subject area, or a related computational field (eg biostatistics, bioinformatics) combined with laboratory experience.
Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at Research Unit meetings is essential, as well as bioinformatics skills, experience in molecular methods and the ability to manage your own academic research and associated activities.
Working experience of sample handling at containment level 2 or 3 and a willingness to work irregular hours and travel (with appropriate prior notice) is desirable.
There will be a substantial laboratory component to the project that will be based in the Genome Centre in central Oxford and on the Old Road campus. However, there will be scope for off-site working for other project-related work.
The post is full time and fixed term for up to 36 months in the first instance.
Applications for this vacancy are to be made online. You will be required to upload a supporting statement and CV as part of your online application.
You are most welcome to directly contact the Theme Lead for Genomics, Tanya Golubchik (email@example.com) or the Unit Director, Peter Simmonds (Peter.Simmonds@ndm.ox.ac.uk) for further information about the Research Unit and its research and development programme.
Only applications received before 12:00 midday on 31/01/2022 will be considered.
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Postdoctoral Fellow 155290 JD