Postdoctoral Research Associate in Computational Biology


University of Oxford, Oxford, UK


  • Posted on: 15th Feb 2021
  • Salary: Grade 8: £41,526 - £49,553 p.a.
  • REF: 149568
  • Closes: 15th March 2021
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Job Details

Postdoctoral Research Associate in Computational Biology

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, Old Road Campus, Oxford, OX3 7FY.

Grade 8: £41,526 – £49,553 p.a.

The groups of Dr Stephen Sansom ( and Professor Paul Bowness at the University of Oxford are looking for a talented computational biologist to join their team. Our research focuses on identifying the cellular and molecular causes of inflammatory arthritis using single-cell and spatial genomics approaches.

In this role, you will help to lead a single-cell genomics based investigation of the cellular basis of ankylosing spondylitis, a common form of inflammatory arthritis. The research will involve the use of cutting-edge statistical and machine learning approaches to model high-dimensional and multi-modal single-cell genomics datasets. The goal of the project is to discover the cells, inter-cellular signalling circuits, biological pathways and genes that are responsible for causing disease directly from patient biopsy samples. The successful applicant will join a team of clinicians and experimental scientists and will also have the opportunity to participate in the Human Cell Atlas project.

You should have a successful track record in academic research that includes the statistical analysis and interpretation of complex genomic datasets, excellent problem-solving abilities and an interest in immunology and inflammatory disease research. A PhD/DPhil (or near completion) in a discipline of direct relevant to computational single cell genomics research is essential. In this role you will perform scientific research, reviewing and refining working hypotheses and developing and acquiring relevant skills as necessary. You will work with Python and R to analyse and interpret data, preparing and publishing your findings in peer-reviewed journals. Experience with the analysis of single-cell RNA-sequencing data is desirable. The successful applicant will be based at the Kennedy Institute of Rheumatology within the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences.

For further information please contact Dr Stephen Sansom:

This is a fixed-term, full time position for 2 years.

A lower grade offer may be made (Grade 7: £32,817 – £ 40,322p.a.) with commensurate reduction in responsibilities if a suitable candidate cannot be found to fill the Grade 8 position

Due to the nature of the research at the Kennedy Institute of Rheumatology, this job will require additional security pre-employment checks:

• A satisfactory basic Disclosure and Barring Service check

The closing date for this position is 12 noon on Monday 15 March 2021. You will be required to upload a CV and supporting statement as part of your online application.

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15-Mar-2021 12:00

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