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Postdoctoral Research Scientist in Cell Biology and Genetics

Physiology Anatomy And Genetics

University of Oxford, Oxford, UK


  • Posted on: 19th Jan 2022
  • Salary: Grade 7: £33,309 - £40,927 p.a.
  • REF: 155693
  • Closes: 16th February 2022
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Job Details

Postdoctoral Research Scientist in Cell Biology and Genetics

Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX

Grade 7: £33,309 – £40,927 p.a.

Full Time, Fixed Term until 31 March 2025 (in the first instance)

Applications are invited for a Postdoctoral Research Scientist position to work on a project to determine the mechanisms regulating amyloidogenesis, using a new live-cell model developed in the fruit fly, Drosophila melanogaster. Amyloid accumulation is associated with several major human diseases, most notably neurodegenerative disorders, but what drives this pathological process is frequently poorly understood. The post-holder will join Professor Clive Wilson’s group, which has recently shown that homologues of two human proteins implicated in pathological amyloidogenesis, Amyloid Precursor Protein (APP; Alzheimer’s Disease) and Transforming Growth Factor-Beta-Induced (TGFBI; corneal dystrophies) have normal roles in protein aggregation. By employing advanced genetic, cell biological and live-cell imaging approaches in Drosophila, the mechanisms controlling these normal aggregation processes, and the genetic and cellular changes that promote formation of altered, pathological amyloid will be determined. The findings will provide an excellent platform for the development of translational collaborative projects in human cells and mammalian models that will test which of these mechanisms can induce amyloidogenic disease.

The post-holder will manage their own research, but will also work with and provide advice to other members of the Wilson research group, including a technician with a direct role in this project. To apply, you must hold, or be close to completion of, a PhD/DPhil in an area relevant to the project, have experience in Drosophila genetics and cell biology, be able to contribute intellectually to advancing the project, and have good data handling, interpersonal and communication skills.

The post is available from 1 April 2022. It is jointly funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC), and will be based in the Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX. Informal enquiries may be directed to Professor Clive Wilson (clive.wilson@dpag.ox.ac.uk). Closing date for applications is midday on Wednesday 16 February. Interviews are likely to be held in the week beginning 21 February.

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion

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16-Feb-2022 12:00

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