Postdoctoral Research Scientist in Disease Gene RegulationWeatherall Institute of Molecular MedicineUniversity of Oxford

Rdm Cardiovascular Medicine

University of Oxford, Oxford, UK

Overview

  • Posted on: 18th Nov 2021
  • Salary: Grade 7: £33,309 - £40,927 per annum
  • REF: 154637
  • Closes: 16th December 2021
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Job Details

Postdoctoral Research Scientist in Disease Gene RegulationWeatherall Institute of Molecular MedicineUniversity of Oxford

RDM Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, OX3 9DU

Grade 7: £33,309 – £40,927 per annum

This is a re-advertisement, previous applicants should not apply

Applications are invited for a highly motivated Postdoctoral Research Scientist to join a programme studying the effect of genome sequence variants and predisposition to cardiovascular disease. The post is funded by the BHF-DZHK and is available immediately fixed-term until 31st August 2023.

The position forms part of a new collaboration between the Division of Cardiovascular medicine and the Weatherall Institute of Molecular Medicine, in the Radcliffe department of Medicine, Oxford.

This project brings together world-leading experts in cardiovascular disease and functional genomics. The successful applicant will join an interdisciplinary team investigating the mechanisms by which non-coding changes in genomic sequences affect gene regulation and disease susceptibility. You will be joining the team that recently decoded the high profile GWAS association that confers a two fold risk of death in COVID infections ( https://doi.org/10.1038/s41588-021-00955-3 ) . Using cutting edge methods to validate the regulatory function of variants the successful applicant will utilise the genomics, bioinformatics, and disease expertise of the Hughes and Watkins Labs.

A biological PhD is required with demonstrable experience in Next Generation Sequencing (NGS), technologies such as epigenomics and/or transcriptomics with basic competence in command line computational environments. Applicants should have enthusiasm and demonstrable knowledge of the key questions and recent developments in human genetics and genome function. The position will employee a pipeline to decode the GWAS signals of cardiovascular disease. This pipeline is comprised of multiple cutting edge genomics and computational methodologies including the highest resolution Chromosome Conformation Capture (3C) methods available; NG Capture-C ( https://doi.org/10.1038/s41467-020-20809-6 ) and MCC ( https://doi.org/10.1038/s41586-021-03639-4 ). These will be used in conjunction with, genome editing, single cell technologies and powerful Deep Neural Network based Machine Learning approaches to predict genome function from sequence (deepC and deepHaem https://doi.org/10.1038/s41592-020-0960-3).

Applications for this vacancy are to be made online; you will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post.

Only applications received before 12.00 midday on 16 December 2021 can be considered. Interviews are scheduled to place on 07 January 2022.

The University is an Equal Opportunity Employer

Contact Person :

Harry Clarke

Vacancy ID :

154637

Contact Phone :

01865234668

Closing Date & Time :

16-Dec-2021 12:00

Contact Email :

cvm_personnel@cardiov.ox.ac.uk

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