Postdoctoral Researcher in DNA repair and genome stability
Department of Oncology, Weatherall Institute for Molecular Medicine, Headington, Oxford
Grade 7: £32,817 – £40,322 per annum
This is a new role within Professor Peter McHugh’s dynamic and ambitious research group studying DNA repair. The appointee will join a team focussing on understanding the structure and function of the human DNA repair nucleases.
The successful candidate will primarily investigate the enzymology, structure and inhibition of these repair factors and will also collaborate with other team members to examine the cellular function and genetics of these repair factors. You will be required to purify recombinant protein from eukaryotic systems, and subsequently perform a number of biochemical and biophysical assays, including in vitro assessments of DNA binding and nuclease activity. You will also be help investigate the structures DNA repair factors using X-ray crystallography and, potentially, cryo-EM.
You will hold, or be close to completion of, a PhD /DPhil in molecular biology, structural biology or biochemistry and will be required to demonstrate experience with molecular cloning, eukaryotic expression, protein purification and crystallisation methods. Experience with biochemical characterisation of enzymes is also desired, preferentially working with nucleic acids modifying proteins. A knowledge of the DNA repair field would be desirable, as would experience in identifying small-molecule inhibitors and molecular probes.
This position is full time and fixed term until 31st December 2022.
All applicants must complete an application form and submit a CV and supporting statement.
The closing date for applications is 12.00 noon on Wednesday, 3rd March 2021.
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Postdoctoral Researcher in DNA repair and genome stability JD