Postdoctoral Researcher in DNA Repair
Department of Oncology, Weatherall Institute for Molecular Medicine, Headington, Oxford
Grade 7: £32,817 – £40,322 per annum
This is a new role within Professor Peter McHugh’s dynamic and ambitious research group studying DNA repair and its role in cancer biology and treatment. The appointee will join a team focussing on understanding the function of human DNA repair enzymes and how these can be exploited to improve cancer treatment.
The successful candidate will primarily investigate the cellular function of multiple repair factors, with a focus on identifying novel genetic interactions. You will be required to generate cell lines with engineered disruptions and alterations in DNA repair factors and utilise these in genetic screens. You will also be required to characterise the DNA repair defects caused by alterations and disruptions in these DNA repair genes using a combination of genetic, cell biology (including imaging), molecular biology and biochemical techniques.
You will hold, or be close to completion of, a PhD /DPhil in molecular biology, biochemistry, cell biology or genetics and will be required to demonstrate experience with molecular cloning, protein purification and biochemical analysis. Experience in CRISPR-Cas9-based methods and genome editing is essential, as is a strong background in general cell and molecular biology. A strong background in cancer cell biology is important and a good knowledge of the DNA repair field is highly desirable.
This position is full time and fixed term for 2 years.
All applicants must complete an application form and submit a CV and supporting statement.
The closing date for applications is 12.00 noon on Monday, 1st March 2021.
Interviews are expected to take place w/c 15th March 2021.
**Please note that there are two posts available for this position. **
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Postdoctoral Researcher in DNA repair