Postdoctoral Researcher in Genome Stability

Cruk/mrc Ox Inst Radiation Oncology

University of Oxford, Oxford, UK


  • Posted on: 16th Nov 2021
  • Salary: Grade 7: £33,309 - £35,326 per annum
  • REF: 154405
  • Closes: 05th January 2022
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Job Details

Postdoctoral Researcher in Genome Stability

Department of Oncology, Old Road Campus Research Building, Headington, Oxford, OX3 7DQ

Grade 7: £33,309 – £35,326 per annum

About the role

Applications are invited from enthusiastic, motivated individuals for a CRUK-funded postdoctoral position in the group of Professor Madalena Tarsounas in the Department of Oncology, University of Oxford. You will join an exciting research programme which combines cell/molecular biology and microscopy approaches with high-throughput technologies (e.g. EdUseq) to understand how BRCA1 and BRCA2 act to facilitate DNA replication, thereby protecting genome integrity. In particular, we aim to monitor genome-wide replication fork progression in BRCA1/2-deficient cells using state-of-the-art technologies (e.g. EdUseq) and to assess the impact of chemotherapeutic drugs on this process (Dagg et al., Nat. Comm. 2021; Tarsounas and Sung, Nat. Reviews Mol. Cell Biology 2020). The project is multi-disciplinary and you will work closely with bioinformaticians. You will provide guidance/supervision as required to other members of the research group, including PhD/MRes students.

In this role, you will work in a team of postdoctoral researchers and graduate students, and will collaborate with researchers from across the University of Oxford’s various technology platforms, as well as from other European Universities. You will be responsible for developing and testing your own hypotheses, generating high-quality and reproducible data, participate in dissemination activities and aid in manuscript preparation.

The start date is essential, and the postholder should ideally be in place by 1 April 2022.

About you

You will have a PhD (or be near to completion) in a relevant area of Biology, Biochemistry, Oncology or other related discipline together with relevant experience. Experience in DNA damage signalling and repair is essential, together with computer literacy and a good record of publication(s) in internationally recognised journals. Experience with analysis of of genomic alterations in cancer would be advantageous.

Application Process

If you would like to discuss this role please contact to Professor Madalena Tarsounas

You will be required to upload a supporting statement (setting out how you meet the selection criteria), a curriculum vitae and the names and contact details of two referees as part of your online application.

Only applications received before noon 5th January 2022 UK time can be considered.

Committed to equality and valuing diversity

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05-Jan-2022 12:00

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Postdoctoral Researcher in Genome Stability Job Description


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