Duties and Responsibilities
The successful candidate will join the research group of Professor Christine Orengo at UCL and work closely with Professor Janet Thornton at EMBL-EBI.
The aim will be to analyse and characterise ligand binding sites in three dimensions to explore the impact of variants on ligand binding. This will involve a detailed analysis of structures in the Protein Databank and also predicted structures. We will associate these data with variants which cause diseases and also consider the frequency of occurrence of variants in humans. We will use our in-house tools to consider Constrained Coding Regions and the conservation of residues in ligand binding sites. We will also use our tools to identify pockets/clefts in protein structures where ligands might bind. We will attempt to link these data to knowledge of pathogenic variants and also to consider the impact of variants on drug efficacy, especially considering genetic backgrounds in different ethnic groups. These data will be combined into prediction algorithms to improve our ability to classify variants as benign or pathogenic, working with clinicians.
The post is funded for two years in the first instance.
PhD (or be studying towards it) in bioinformatics or computational biology or relevant subject area. Extensive experience of protein structure analysis and computational biology approaches to analysing molecular and medical information. You should also be familiar with variant classifications and genetic data.
Please note: Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B (Salary 32,217 – 33,958 per annum, including London Allowance) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis (including corrections).
A job description and person specification, can be accessed at the bottom of this page. Please ensure you read these carefully before applying for the post.
To apply for the vacancy please click on the ‘Apply Now’ button below.
For informal enquiries about the post please contact Christine Orengo at email@example.com
If you have any queries regarding the application process please contact Biosciences staffing at firstname.lastname@example.org quoting the vacancy reference number: 1879004.
UCL Taking Action for Equality
We will consider applications to work on a part-time, flexible and job share basis wherever possible.
29 Sep 2021
Latest time for the submission of applications
Our department holds an Athena SWAN Bronze award, in recognition of our commitment to advancing gender equality.
This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff.
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