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Research Associate

Institute of Immunology and Immunotherapy

Birmingham, United Kingdom

Overview

  • Posted on: 13th Dec 2021
  • Salary: £31,406
  • REF: 98852
  • Closes: 16th January 2022
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Background
To assist in research (by carrying out data collection or analyses) to create knowledge through providing research support for projects and research groups.
To evaluate the activity of a metabolic therapy against a spectrum of cancer models

Summary of Role
• Work within specified research grants and/or projects
• Operate within area of specialism
• Contribute to publications

The Mussai-De Santo laboratory at the University of Birmingham has demonstrated that tumour cells have increased metabolic requirements. Targeting of tumour cell metabolism can lead to decreased cell proliferation and tumour cell death.

In this project the candidate will investigate the potential of targeting an alternative metabolic pathway using a therapeutic enzyme or inhibitor cultured with target cells in vitro.

Main Duties / Responsibilities
• Collect research data; this may be through a variety of research methods, such as scientific experimentation, literature reviews, and research interviews
• Analyse research data as directed
• Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
• Develop or adapt techniques, models and methods
• Provide guidance as required to support staff and any students who may be assisting with research
• Deal with problems that may affect the achievement of research objectives and deadlines
• Carry out administrative tasks related directly to the delivery of the research
• Promotes equality and values diversity acting as a role model and fostering an inclusive working culture
Duties specific to this project will include
• Culture and maintenance of human cancer cell lines in vitro
• Drug dilution and cell culture treatments
• Handling and processing of primary human blood/ tumour sample
• Magnetic Cell sorting of target cell propulations
• Multi-colour flow cytometry for cell surface markers, intracellular markers, assays for cell viability and proliferation
• Standard molecule biology techniques (e.g. ELISA, Western Blotting, qPCR)
• Measurement of target metabolite concentration by colorimetric assays

Person Specification
• Degree or equivalent in relevant subject area (First degree in area of biological specialism is mandatory)
• Practical experience of applying the relevant skills and techniques
• Ability to analyse information and communicate effectively
• Ability to access and organise resources successfully
• Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day to day activity in own area that those with protected characteristics are treated equally and fairly
• Ability to competently use core laboratory techniques (not limited to) tissue culture, flow cytometry immunophenotyping, human blood and tissue cell separation and isolation (Lymphoprep and MACS sorting), ELISA, Western Blotting, and molecular biology is mandatory

Informal enquires to Dr Frank Mussai (f.j.mussai@bham.ac.uk)

Valuing excellence, sustaining investment

We value diversity and inclusion at the University of Birmingham and welcome applications from all sections of the community and are open to discussions around all forms of flexible working

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