Applications are invited for a Bioinformatician to join Professor Patrick Chinnery`s group investigating to role of somatic DNA mutations in brain ageing and neurodegenerative diseases. We are seeking a talented research associate in computational biology/computer science/bioinformatics to join a team of clinical and laboratory scientists who are studying the role of genetic variation in brain ageing and disease. The team publishes high-profile publications including Science, Nature Cell Biology (Nature Genetics 2020:in press; Science. 2019 May 24;364(6442); Nat Cell Biol. 2018 Aug;20(8):991).
Professor Chinnery’s research group is mapping the trajectory of somatic mutations across the brain throughout the life course using state of the art single cell genomics at scale, in health and disease. The post holder will perform the primary analysis of this unique dataset using computational and bioinformatics approaches. It is anticipated that the work will cast light on the fundamental biology of ageing and neurodegenerative diseases including Alzheimer’s and Parkinson’s disease by linking developmentally acquired mutations to cell function through single cell RNA sequencing data on a massive scale. The role holder will closely collaborate with computer scientists and bioinformaticians hosted by Prof Nick Jones at the Department of Mathematics, Imperial College London. In addition, the post holder will work closely with other bioinformaticians, laboratory and clinical scientists in the University, Wellcome Sanger Institute, and The European Bioinformatics Institute, as well as other bioinformatics teams across the campus.
The post holder will have the opportunity to work on a range of experimental and publicly available datasets, including long and short-read whole genome sequencing (e.g. Illumina and Oxford Nanopore sequencing), whole exome sequencing, ultra-high depth DNA and RNA sequencing of the nuclear and mitochondrial genomes, single cell DNA-sequence and transcriptomic data, and epigenomic datasets. In addition to their own research, there will be opportunities for training and career development.
Post graduate education in computational biology at PhD level, ideally involving bioinformatics/ computational biology is essential.
For questions relating to the post, please contact Professor Patrick Chinnery: firstname.lastname@example.org
Fixed-term: The funds for this post are available until 28th February 2023 in the first instance.
Closing date for application is 7 March 2021 with interview date to be confirmed.
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Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference RR25686 on your application and in any correspondence about this vacancy.
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