The Ahringer laboratory at the Wellcome/CRUK Gurdon Institute is seeking a talented and motivated Bioinformatics Research Associate to join their research laboratory. Our research programmes aim to decipher how eukaryotic gene expression and genome architecture are regulated in development, using the powerful and tractable model organism C. elegans (http://www.ahringer.group.gurdon.cam.ac.uk/). We study how differential control of regulatory elements, chromatin domains, and 3D genome organization establish gene expression programmes that drive cellular identity.
The post will particularly focus on investigating the control and role of genome architecture in development through developing and applying methods to analyze data derived from ARC-C, our new method that maps chromatin interactions genome-wide at 500bp resolution: https://www.biorxiv.org/content/10.1101/467506v1.
You will also actively and collaboratively contribute to different projects within our lively research laboratory, using existing cutting-edge software or devising new methods to analyse genomic, transcriptomic and epigenomic data (e.g, ChIP-seq, ATAC-seq, RNA-seq, Hi-C, single-cell analyses), and be responsible for maintaining our database of sequencing datasets.
You will have a strong background in bioinformatics and statistics, prior experience in the analysis of high-throughput genomic and transcriptomic data, and excellent computer skills (in programming and sequencing analysis software). Prior experience in the analysis of chromatin interaction data would be an advantage. You should also have a PhD in a relevant subject, a sound understanding of molecular biology, and a strong publication track record in bioinformatics. You will be expected to be able to work independently and interact well in a dynamic multidisciplinary team environment, and be able to communicate ideas and results clearly.
We are located in the Wellcome/Cancer Research UK Gurdon Institute, a world-renowned centre of Developmental biology and Cancer research embedded in the University of Cambridge. The Institute provides an exceptional and stimulating environment that promotes collaborative and interdisciplinary research in a supportive and modern setting, with access to state-of-the-art technologies such as super-resolution imaging, single-cell analyses, genome engineering, and genomics and computer modelling. Its postdoc association encourages scientific and social interactions and also provides career development and teaching opportunities.
Fixed-term: The funds for this post are available for 3 years in the first instance.
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