Applications are invited for three Research Associate positions that have become available in the laboratory of Prof. Luca Pellegrini in the Department of Biochemistry of the University of Cambridge, UK.
Work in the laboratory is focused on elucidating the structural basis for eukaryotic DNA replication (Rzechorzek et al, NAR, 2020; Evrin et al, EMBOJ, 2018; Villa et al, Mol Cell, 2016; Simon et al, Nat Comm, 2016; Simon et al, Nature, 2014) and associated DNA repair processes (Lerner et al, EMBOJ, 2020; Brouwer et al, EMBOJ, 2018).
The aim of the project is to elucidate key molecular mechanisms of DNA synthesis by the human replisome, the dynamic multi-protein ensemble responsible for duplicating chromosomal DNA before cell division. To achieve this goal, the successful candidates will use a multi-disciplinary approach that includes preparative biochemistry of multi-protein complexes, protein engineering and state-of-the-art biophysical and structural techniques.
The project will advance our understanding of how our cells copy their DNA and thus maintain genomic stability across cellular generations. In addition to its biological importance, such information will have great medical relevance, as disease such as cancer and premature aging are promoted by errors in our genome caused by defective replication.
Successful candidates will hold or be about to be awarded a PhD in Biochemistry, Biophysics or Molecular Biology. They must have a track record in conducting internationally competitive research, including peer-reviewed publications as first author.
The ideal candidate will combine an ability to work independently and to fit in well in a team. Above all, she/he will be enthusiastic about pursuing fundamental research and be highly motivated to succeed professionally.
Expert knowledge of modern methods of preparative biochemistry and/or of quantitative biophysical methods is required. In particular, expertise in one or more of the following techniques is essential:- Mammalian/insect-cell protein expression, – cryoEM (SPA and/or tomography), – single-molecule fluorescence analysis
Applicants should submit a CV with list of relevant publications, a cover letter explaining why they are suitable for the position and contact information for at least two referees.
Fixed-term: The funds for this post are available for 60 months in the first instance.
Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.
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Please quote reference PH25609 on your application and in any correspondence about this vacancy.
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