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Senior Research Associate

Department of Clinical Neurosciences

University of Cambridge, Trinity Ln, Cambridge, UK


  • Posted on: 16th Jan 2022
  • Salary: £42,149-£53,348
  • REF: ZE29745
  • Closes: 28th February 2022
  • Contract Type: Fixed-Term/Contract
  • Hours: Full Time

Applications are invited for a Senior Research Associate position at the UK Dementia Research Institute (UK DRI), at the University of Cambridge, Department of Clinical Neurosciences. The post is within a collaboration between the laboratories of Professor Sir David Klenerman at the UK DRI and Professor Maria Grazia Spillantini in the Department of Clinical Neurosciences. The project aims to study how protein homeostasis is disrupted in human derived IPSC neurons leading to the formation of increased numbers of tau aggregates and how aggregates spread from neuron to neuron by super-resolution imaging of the aggregates formed in and secreted by the neurons.

Dementia is the greatest health challenge of our century.To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap. We are a globally leading multidisciplinary research institute of 700 staff investigating the spectrum of neurodegenerative disorders causing dementia, with laboratory-based research groups located at University College London, the University of Cambridge, Cardiff University, Edinburgh University, Imperial College London and King’s College London.

CambridgeDeveloping new treatments that can prevent the onset of dementia or protect neurons from damage is hindered by our lack of knowledge in the fundamental causes and mechanisms behind neurodegeneration. Scientists at the UK DRI at Cambridge use cutting-edge approaches to build our understanding of the biological processes behind the earliest stages of neurodegeneration and ageing. They explore mechanisms causing the loss of vital connections between neurons and the pathways that drive repair of these connections, which are essential for memory formation and survival of brain cells and identify key molecular targets for translation into effective treatments to stop, slow or reverse dementia.

We are now looking for an experienced postdoctoral research associate to work on analysis of tau aggregation in iPSC-derived neurons and glia (astrocytes, microglia, oligodendrocytes) from patients with inherited tauopathies. Expertise is required in maintenance and differentiation of IPSC lines, and advanced biochemical, cell, and molecular biological techniques, including proteomic analysis of conditioned media, RNA and protein analysis of cells, and experience in cell stress induction and analysis.

The post holder will have a PhD and expertise in culturing stem cells, on astrocyte biology, and in particular on different types of cell stress induction and analysis.

For informal enquires please contact Prof Sir David Klenerman dk10012@cam.ac.uk or Professor Maria Grazia Spillantini mgs11@cam.ac.uk

Fixed-term: The funds for this post are available until 28 February 2023 in the first instance.

Appointment to Senior Research Associate is subject to approval by the Faculty Board of Clinical Medicine

Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online.

Closing Date: 28th January 2022

Interview Date: 3rd February 2022

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference ZE29745 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Further information

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